index - Laboratoire de recherche européen pour la polyarthrite rhumatoïde Access content directly

EUROPEAN RESEARCH LABORATORY FOR RHEUMATOID ARTHRITIS – GENHOTEL

European research laboratory for rheumatoid arthritis - GenHotel is a research unit of University of Evry since 1999 on the Genopole campus. For nearly 20 years, our lab has focused on the aetiology of a complex disease, rheumatoid arthritis (RA). After a period consisted of 'classical' genetic analyses through linkage and association studies, results, and particularly GWAS one, lead us to develop alternative approaches. Instead of considering common genomic variants, we decided to focus on rare and specific ones, to identify biomarkers in RA and its phenotypes. In this direction, we developed a global approach to the disease by mapping all the connections. Based on these approaches, our research activity is divided into two main axis: Characterization of new RA genomic variants and Computational systems biology approaches for the construction of graphical and dynamical models of disease mechanisms to study their complex dynamic behavior. Results of the first axis feed the second project, contributing to the development of a pipeline for identifying new lines in RA drug design.

Documents avec texte intégral

32

Références bibliographiques

134

Mots-clés

Alleles Algerian population Ankylosing spondylitis ATP Binding Cassette Transporter Europe HLA-DRB1 Polymorphism Age Factors Non-Receptor Type 22 Génétique Shared Epitope Gene Frequency Antibodies Risk Factors APOPTOSIS Complex genetic disease Autoimmunity RHEUMATOID ARTHRITIS Anti-citrullinated protein antibodies France Young Adult Biologie des systèmes Phenotype Middle Aged ASSOCIATION STUDY Haplotypes HLA-DRB1 Chains Autoantibody Production Genotype Family Health Binding Sites In silico simulations Rare variants Humans Reproducibility Genetic Predisposition to Disease Antigen Presentation Linkage Disequilibrium 80 and over Rheumatoid Arthritis Case-Control Studies Rheumatoid Factor ABCB1 Polyarthrite rhumatoïde Computational biology Hybrid modeling Databases European Continental Ancestry Group Rheumatoid Arthritis Patient Biological pathway Logical modelling Receptors Biologie computationnelle des systèmes POLYMORPHISM Single Nucleotide Systems biology Autoimmune thyroid disease Autoimmune Diseases Computational modeling Antigens Antirheumatic Agents Rheumatoid Biocuration Tunisia Female Metabolic reprogramming HLA-DR Antigens Annotation standards Computational systems biology Autoimmune thyroid diseases Cohort Studies Arthritis Animals Genetic Association Studies Environment Human genomics Adolescent Family Disease maps Age of Onset Autoantibodies Transcriptome PTPN22 gene Rheumatoid arthritis Association study Genetics Analysis Epitopes Ankylosing African Continental Ancestry Group Adult Anti-Idiotypic Aged Network inference Odds Ratio Protein Tyrosine Phosphatase Genetic Genetic Linkage Algeria Male

Derniers dépôts

Chargement de la page

Collaboration à l'international